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CD46 database. The course and outcome of the disease are influenced by the gene in which pathogenic variants occur:. Vaccination against Neisseria meningitides tetravalent vaccine A, C, Y, W is mandatory two weeks before administration of eculizumab. Homozygous or compound heterozygous pathogenic variants in DGKE. A clinical trial is currently evaluating the efficacy and safety of crovalimab in adult and adolescent participants with aHUS. In the families reported to date with polygenic inheritance, heterozygotes have usually been asymptomatic. A novel deletion in the RCA gene cluster causes atypical hemolytic uremic syndrome. Differences in perspective may exist among medical professionals and within families regarding the use of prenatal testing. Hum Genet.
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